Answer
Smoking increases CYP1A2 activity and can reduce agomelatine exposure, especially with heavy smoking. A prescriber should know if smoking habits change.
Sources for this answer
- Agomelatine Zentiva 25 mg film-coated tablets — Current selected SmPCemc · Summary of Product Characteristics
- Valdoxan — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.