Answer
Semaglutide itself is not expected to reduce oral contraceptive exposure significantly. However, contraception is required because semaglutide should not be used during pregnancy, and vomiting or severe diarrhoea should be managed using the pill’s missed-dose instructions.
Sources for this answer
- Wegovy 2.4 mg, FlexTouch solution for injection in pre-filled pen — Current selected SmPCemc · Summary of Product Characteristics
- UK Government