Answer
The selected product information reports no significant change in serum half-life in severe renal impairment and no expected accumulation at usual prescribed exposure, although clinical context still matters.
Sources for this answer
- Doxycycline 100 mg Capsules — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.