methotrexate sodium · Medicine question

Does methotrexate pass into breast milk?

iatroX medicinesPublished 8 November 2026

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Methotrexate passes into breast milk; because serious adverse reactions may occur in nursing infants, a decision must be made whether to stop breastfeeding or the drug, taking into account the drug’s importance to the woman.

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Methotrexate 25 mg/ml InjectionHospira UK Ltd · emc · SmPC §4.6 Fertility, pregnancy and lactation · Version 28Document updated 7 September 2026

Sources checked 8 November 2026

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Can methotrexate reduce fertility, and are these effects usually reversible after treatment stops?How long must women use effective contraception after stopping methotrexate?Are any pharmaceutical incompatibilities specified for Methotrexate 2.5 mg Tablets, the Morningside Healthcare Ltd product?Are vials of Methotrexate 25 mg/ml Injection, the Hospira UK Ltd product, single-use, and what should happen to unused contents?By which routes can Hospira UK Ltd's Methotrexate 25 mg/ml Injection be administered?

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