Answer
Yes. Long-term treatment should be reviewed because PPIs can be associated with low magnesium, reduced vitamin B12 absorption, fractures and gastrointestinal infections in susceptible people.
Sources for this answer
- Rabeprazole sodium 20 mg gastro-resistant tablets — Current selected SmPCemc · Summary of Product Characteristics
- Pariet 20mg tablets — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.