Answer
It can interact with several painkillers: tramadol may increase seizure risk, opioids may increase sedation and buprenorphine may contribute to serotonin syndrome.
Sources for this answer
- Lofepramine 70mg/5ml Oral Suspension — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.