Answer
Yes. Impairment can increase exposure and requires product-specific assessment. Hepatic impairment is a contraindication to the selected prolonged-release capsule.
Sources for this answer
- Palladone SR 8mg capsules — Current selected SmPCemc · Summary of Product Characteristics
- Palladone 10 mg/ml solution for injection or infusion — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.