Answer
Yes. Clearance may be reduced and uraemia can worsen marrow suppression, so renal function and toxicity require close specialist assessment.
Sources for this answer
- Melphalan 50 mg powder and solvent for solution for injection/infusion — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.