Answer
Yes. Paracetamol with flucloxacillin has been associated with high-anion-gap metabolic acidosis, particularly in people with severe illness, renal impairment, malnutrition or chronic alcohol use.
Sources for this answer
- Panadol Extra Advance/ Panadol Period Pain 500mg/65mg Tablets (GSL) — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.