Clinical CPD topic
Methotrexate safety: practise, reflect and record
Practise methotrexate safety through five clinical cases, review the explanations and build a professional learning record. Select baseline safety checks and prevent erroneous daily methotrexate prescribing.
First published · Sources checked
What you’ll work on
- Select baseline safety checks and prevent erroneous daily methotrexate prescribing.
- Recognise the hazardous methotrexate–trimethoprim interaction.
- Act appropriately on deteriorating renal function and suspected pulmonary toxicity.
Think through a clinical case
Decide how you would approach this case before opening the question session.
A patient with psoriasis is about to start methotrexate. Which baseline bundle is required before the first dose?
A case from the UKMLA question bank. The session provides the answer and explanation after your attempt.
From a decision to a learning record
- Test your reasoning. Answer five questions from this topic’s clinical-content library.
- Explore the gaps. Review explanations and use Tutor to work through decisions that need more thought.
- Reflect on application. Describe what you learned and what you would change or investigate.
- Review your evidence. Confirm the activity and time spent, then retain or export your professional record.
Primary sources and further reading
Read the source in the same jurisdiction as your question session.
- Methotrexate monitoring – NHS SPS - Specialist Pharmacy Service – The first stop for professional medicines adviceUK source
- Methotrexate 2.5 mg Tablets — UK SmPCUK source
- Methotrexate once-weekly for autoimmune diseases: new measures to reduce risk of fatal overdose due to inadvertent daily instead of weekly dosing - GOV.UKGOV.UKUK source
- Managing interactions with methotrexate – NHS SPS - Specialist Pharmacy Service – The first stop for professional medicines adviceUK source
- Methotrexate 25 mg/ml Injection — UK SmPCUK source