ToxBase vs BNF (2025): Overdose Management vs Prescribing Safety
At a Glance
Who is it for?
ToxBase:Emergency / Acute Medics
BNF:All Prescribers
Why choose ToxBase?
- The ONLY authority for overdose management in the UK
- Live updates on novel recreational drugs
- Specific nomograms (e.g. Paracetamol)
Why choose BNF?
- The authority for *therapeutic* dosing
- Lists side-effects, not overdose protocols
- Universal access
Feature Comparison
| Capability | ToxBase | BNF |
|---|---|---|
| Pricing | Free (NHS Login required) | Free (Open Access) |
| Access | Registration mandatory (Security) | Open App / Web |
| Primary Strength | Acute Toxicity Management | Safe Prescribing |
| Content | Antidotes, decontamination, observation | Doses, interactions, cautions |
In-Depth Analysis
Overview
ToxBase is the clinical toxicology database of the UK National Poisons Information Service. It is specialized, secure, and focused entirely on the management of poisoning—whether from pharmaceuticals, household products, or industrial chemicals.
The BNF is the formulary for prescribing. While it contains a chapter on poisoning, it explicitly defers to ToxBase for detailed management.
Key Differences
This is a safety-critical distinction. Never use the BNF to manage an acute overdose if ToxBase is available. ToxBase contains the dynamic, step-by-step protocols (including decontamination and specific antidotes) that the BNF does not cover.
Use-Cases
Paracetamol Overdose
When to choose ToxBase
- Use ToxBase. It has the official weight-adjusted NAC treatment graph.
When to choose BNF
- Do NOT use. It will list the therapeutic dose, not the complex overdose protocol.
Checking Interactions
When to choose ToxBase
- Limited. Focuses on toxicity.
When to choose BNF
- Essential. Check if the patient's new meds interact with their current ones.