Perplexity vs iatroX (2025): The Search Engine vs The Medical Device

Last reviewed: 2025-12-19 · Reviewed by Dr Kola Tytler, MBBS CertHE MBA MRCGP

At a Glance

Who is it for?

iatroX:Clinicians treating patients.

Perplexity AI:Researchers & General Public.

Why choose iatroX?

  • **Clinical Governance**: UKCA-marked medical device designed for safety.
  • **Walled Garden**: Only searches trusted UK sources (NICE, CKS, BNF).
  • **Hallucination Control**: Strict RAG architecture prevents inventing treatments.
  • **Context**: Understands 'first-line', 'contraindication', and medical nuance.

Why choose Perplexity AI?

  • **Web Access**: Can read news articles, forums, and US websites.
  • **Breadth**: Answers non-medical questions ('Who won the football?').
  • **Source Variety**: Links to blogs, PDFs, and YouTube videos.
  • **Speed**: Extremely fast web crawling.

Feature Comparison

CapabilityiatroXPerplexity AI
SafetyHigh (Regulated Device)Variable (Generalist AI)
SourcesCurated GuidelinesThe Entire Internet
BiasUK / NHSUS / Commercial Web

In-Depth Analysis

Overview

Perplexity is an incredible "Answer Engine." It replaces Google for many people. However, in medicine, "The Internet" is often wrong. Perplexity might build a convincing answer based on a blog post from 2015 or a US-based health site that conflicts with NHS protocols.

iatroX is a Medical Device. It does not search the internet. It searches a secure, updated vault of UK National Guidelines. When it answers, it is not "guessing" based on web probability; it is retrieving the specific paragraph from NICE that governs your practice.

Key Differences

Perplexity prioritizes relevance and speed (finding an answer). iatroX prioritizes safety and governance (finding the correct answer).

Use-Cases

Prescribing for a Child

When to choose iatroX

  • **Essential.** Checks the BNFc and NICE guidelines for safe dosing.

When to choose Perplexity AI

  • **Risk.** May source a dose from a US forum or outdated blog post.

Finding a Rare Paper

When to choose iatroX

  • N/A

When to choose Perplexity AI

  • **Winner.** Excellent at finding specific PDFs on the web.

Checking a Guideline

When to choose iatroX

  • **Winner.** Guaranteed to quote the current UK standard.

When to choose Perplexity AI

  • Might quote the Mayo Clinic (US) or a guideline from 2018.

FAQs

Is Perplexity safe for medical advice?
Perplexity states it is not a medical device and should not be used for clinical decisions. iatroX is UKCA-marked for this purpose.