OpenEvidence vs Medwise AI (2025): Public Evidence vs Enterprise Search

Last reviewed: 2025-12-19 · Reviewed by

At a Glance

Who is it for?

OpenEvidence:Individual Clinicians

Medwise AI:NHS Trusts / Organisations

Why choose OpenEvidence?

  • **Global Literature**: Scans millions of papers to answer clinical questions.
  • **Evidence Grading**: Provides citations and confidence levels for claims.
  • **Free Access**: Generally open to verified clinicians.

Why choose Medwise AI?

  • **Local Content**: Indexes your Trust's intranet, PDFs, and local protocols.
  • **Governance**: Only shows approved documents from your organisation.
  • **Analytics**: Tracks what staff are searching for to identify knowledge gaps.

Feature Comparison

CapabilityOpenEvidenceMedwise AI
SourcePubMed / Medical WebInternal Documents / Intranet
ScopeUniversal MedicineLocal Operations
ModelB2C (Individual)B2B (Enterprise)

In-Depth Analysis

Overview

OpenEvidence is for asking "What is the best way to treat this?" based on global science.

Medwise AI is for asking "What is our way to treat this?" based on local policy. Hospitals procure Medwise to stop staff struggling to find PDFs on a clunky intranet.

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Use-Cases

How do I treat Sarcoidosis?

When to choose OpenEvidence

  • **Winner.** Summarises the latest evidence and trials.

When to choose Medwise AI

  • Only useful if your hospital has a specific sarcoidosis policy.

What is the extension for the Cardio Reg?

When to choose OpenEvidence

  • N/A

When to choose Medwise AI

  • **Winner.** Finds the local rota or phone directory document.