alprostadil · Medicine question

Can Viridal Duo (alprostadil) cause penile fibrosis?

iatroX medicinesPublished 8 November 2026

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Viridal Duo (alprostadil) can cause penile fibrosis following intracavernosal injection, with occurrence potentially increasing with longer use; regular penile examination is strongly recommended, and treatment should stop if penile angulation, cavernosal fibrosis or Peyronie’s disease develops.

Sources for this answer

Viridal Duo 10 micrograms/ml Powder and Solvent for Solution for InjectionADVANZ Pharma · emc · SmPC §4.4 Special warnings and precautions for use · Version 31Document updated 15 September 2026

Sources checked 8 November 2026

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How common is apnoea in newborns with congenital heart defects receiving Prostin VR (alprostadil)?Can men with penile implants use Viridal Duo (alprostadil)?What is Viridal Duo (alprostadil) used for in adult men?What solvent is provided to reconstitute Viridal Duo (alprostadil) powder for injection?Where is Viridal Duo (alprostadil) injected for erectile dysfunction?Have interactions been reported between Prostin VR (alprostadil) and penicillin or gentamicin in newborns with congenital heart defects?

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