Answer
Kidney impairment can increase varenicline exposure. Renal function should be assessed and the product is not recommended in end-stage renal disease because clinical experience is insufficient.
Sources for this answer
- Varenicline 0.5 mg film-coated tablets — Current selected SmPCemc · Summary of Product Characteristics
- NHSNHS · NHS medicine guidance
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.