Answer
Yes, tolerance to isosorbide dinitrate and cross-tolerance following prior treatment with another nitrate have been described; continuously high dosages must be avoided to prevent decreased or lost effect.
Sources for this answer
- Isosorbide Dinitrate 0.1%w/v Concentrate for Solution for Injection or InfusionTorbay Pharmaceuticals Limited · emc · SmPC §4.4 Special warnings and precautions for use · Version 6Document updated
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