Answer
Yes. Tolerance, physical dependence and opioid use disorder can occur, particularly with longer exposure.
Sources for this answer
- UK GovernmentUK Government · Reputable Web
- Ationdo SR 25mg prolonged release tablets PL 50414/0004 — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.