Answer
Cobicistat commonly raises serum creatinine by reducing its tubular secretion, which may lower creatinine-based eGFR without reducing true glomerular filtration. Tenofovir alafenamide can also rarely cause genuine kidney injury.
Sources for this answer
- Symtuza 800 mg/150 mg/200 mg/10 mg film coated tablets — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.