Can sulfamethoxazole + trimethoprim raise potassium levels?

iatroX medicinesPublished 21 August 2026Reviewed 21 August 2026

The answer

Answer

Yes. Clinically important hyperkalaemia can occur, especially with kidney impairment or other potassium-raising medicines.

Co-Trimoxazole 80 mg/400 mg Tabletsemc · SmPC Current selected SmPC · Version 12

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sulfamethoxazole + trimethoprim · Medicine question

iatroX medicinesPublished 21 August 2026Reviewed 21 August 2026

The answer

Yes. Clinically important hyperkalaemia can occur, especially with kidney impairment or other potassium-raising medicines.

Co-Trimoxazole 80 mg/400 mg Tabletsemc · SmPC Current selected SmPC · Version 12

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