Can sulfamethoxazole + trimethoprim be taken with methotrexate?

iatroX medicinesPublished 21 August 2026Reviewed 21 August 2026

The answer

Answer

The combination should usually be avoided because severe, sometimes delayed bone-marrow suppression can occur.

NHS Specialist Pharmacy ServiceNHS Specialist Pharmacy Service · NHS medicine guidance

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sulfamethoxazole + trimethoprim · Medicine question

iatroX medicinesPublished 21 August 2026Reviewed 21 August 2026

The answer

The combination should usually be avoided because severe, sometimes delayed bone-marrow suppression can occur.

NHS Specialist Pharmacy ServiceNHS Specialist Pharmacy Service · NHS medicine guidance

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