siltuximab · Medicine question

Can siltuximab increase cholesterol and triglyceride levels?

iatroX medicinesPublished 8 November 2026

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Yes, elevations in cholesterol and triglycerides were observed in patients treated with Sylvant (siltuximab), and patients should be managed according to current clinical guidelines for hyperlipidaemia.

Sources for this answer

SYLVANT 100 mg powder for concentrate for solution for infusionRecordati UK Ltd · emc · SmPC §4.4 Special warnings and precautions for use · Version 12Document updated 28 June 2024

Sources checked 8 November 2026

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Has the safety and efficacy of siltuximab been established in children aged 17 years or younger?Have the effects of siltuximab on human fertility been evaluated?How does siltuximab block interleukin-6 signalling?How long must women of childbearing potential use effective contraception after siltuximab treatment?What does Sylvant (siltuximab) powder for concentrate for solution for infusion look like before reconstitution?What was the most serious adverse reaction associated with siltuximab?

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