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Medicines carbidopa + levodopaQuestion & answer

carbidopa + levodopa · Medicine question

Can prolonged-release tablets be crushed?

iatroX medicinesPublished 19 August 2026Reviewed 19 August 2026

The answer

Answer

No. They must be swallowed whole because chewing, crushing or halving damages the controlled-release system.

Sources for this answer

Sinemet CR and Half Sinemet CRemc · SmPC Current selected SmPC · Version 18

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The full medicine guide

carbidopa + levodopa

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