Answer
Yes. It has been associated with ovarian failure and absence of sperm production, which may be irreversible; fertility preservation should be discussed before treatment where feasible.
Sources for this answer
- Procarbazine Capsules 50mg — Current selected SmPCemc · Summary of Product Characteristics
- NHSNHS · NHS medicine guidance
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.