Answer
Because pemetrexed is mainly cleared by the kidneys, reduced renal function can increase exposure and toxicity. Use is not recommended below the product’s specified creatinine-clearance threshold.
Sources for this answer
- Alimta 100mg and 500mg powder for concentrate for solution for infusion — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.