Answer
Pemetrexed is mainly cleared by the kidneys. The selected product is not recommended below a creatinine clearance of 45 mL/min because adequate safety data are unavailable.
Sources for this answer
- Pemetrexed 25mg/ml concentrate for solution for infusion — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.