Answer
Yes, pegvisomant can cause a growth hormone-deficient state despite elevated serum growth hormone levels; serum IGF-I concentrations should be monitored and maintained within the age-adjusted normal range by adjusting the pegvisomant dose.
Sources for this answer
- SOMAVERT 10mg powder and solvent for solution for injectionPfizer Limited · emc · SmPC §4.4 Special warnings and precautions for use · Version 26Document updated
Sources checked