Answer
Liver impairment can increase toxicity, particularly bone-marrow suppression. Restrictions differ by formulation, and severe impairment excludes conventional paclitaxel treatment.
Sources for this answer
- Abraxane 5 mg/ml powder for dispersion for infusion — Current selected SmPCemc · Summary of Product Characteristics
- Paclitaxel 6 mg/ml concentrate for solution for infusion — Current selected SmPCemc · Summary of Product Characteristics
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