Answer
Yes. Rapid opioid reversal can cause agitation, sweating, nausea, vomiting, pain, rapid heartbeat and raised blood pressure, particularly in someone physically dependent on opioids.
Sources for this answer
- Naloxone 400 micrograms/ml solution for Injection/Infusionemc · SmPC Current selected SmPC · Version 8
- Nyxoid 1.8 mg nasal spray, solution in a single-dose container