Answer
Yes. Anxiety, depression, abnormal dreams and insomnia can occur, and rare serious reactions include hallucinations, paranoia and suicidal thoughts. New mental changes during prevention require stopping mefloquine and immediate medical review.
Sources for this answer
- Lariam 250 mg tablets / Mefloquine 250 mg tablets — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.