Answer
Yes. Kidney impairment can increase lamivudine exposure, while liver impairment can increase abacavir exposure. The fixed combination may be unsuitable when component-specific adjustment is needed.
Sources for this answer
- Abacavir/Lamivudine 600mg/300mg Film-coated tablets — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.