Answer
Yes. Small amounts can be absorbed, so heart, lung and other effects associated with beta blockers or sulfonamides remain possible.
Sources for this answer
- Dorzolamide/Timolol 20mg/ml + 5mg/ml eye drops, solution in single-dose container — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.