Answer
Yes. Suppression of ACTH can reduce cortisol too far, causing marked weakness, nausea, vomiting, weight loss or low blood pressure.
Sources for this answer
- Signifor 10 mg powder and solvent for suspension for injection — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.