Answer
Yes. Severe or persistent diarrhoea during or after treatment needs prompt medical assessment because it may indicate antibiotic-associated colitis.
Sources for this answer
- Piperacillin/Tazobactam 2 g / 0.25 g powder for solution for infusion — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.