Answer
Yes. Repeated tramadol use can cause tolerance, physical dependence and opioid-use disorder, including when taken as prescribed.
Sources for this answer
- Tramacet 37.5 mg/ 325 mg film-coated tablets — Current selected SmPCemc · Summary of Product Characteristics
- NHSNHS · NHS medicine guidance
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.