Answer
Yes. Repeated codeine use can cause tolerance, dependence and opioid use disorder, including at therapeutic doses. Warning signs include wanting more or feeling unwell when stopping and better after restarting.
Sources for this answer
- Boots Ibuprofen and Codeine 200mg/12.8mg film-coated Tablets — Current selected SmPCemc · Summary of Product Characteristics
- UK GovernmentUK Government · Reputable Web
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.