Answer
It is not significantly metabolised by the liver, and its kinetics are unchanged in mild or moderate hepatic impairment. Safety and efficacy in severe hepatic insufficiency have not been established.
Sources for this answer
- Acamprosate 333 mg Gastro-resistant Tablets.emc · SmPC Current selected SmPC · Version 4
- Campral ECemc · SmPC Current selected SmPC · Version 13