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Medicines diclofenac sodium + misoprostolQuestion & answer

diclofenac sodium + misoprostol · Medicine question

Can it be used while breastfeeding?

iatroX medicinesMedicine guide reviewed 19 August 2026

The answer

Answer

No. Active misoprostol metabolite enters breast milk and could cause diarrhoea in the infant.

Sources for this answer

Arthrotec 50 Tablets — Current selected SmPCemc · Summary of Product Characteristics
Arthrotec 75 modified-release Tablets — Current selected SmPCemc · Summary of Product Characteristics
NHS Specialist Pharmacy Service

NHS Specialist Pharmacy Service · NHS medicine guidance

General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.

The full medicine guide

diclofenac sodium + misoprostol

Read the wider context, including uses, precautions and the sources behind this medicine guide.

Read the diclofenac sodium + misoprostol guide

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More questions about diclofenac sodium + misoprostol

Why does this combination contain two active ingredients?Does it prevent every stomach ulcer?Can the tablets be crushed or chewed?Can I take ibuprofen with it?What should I do if it causes diarrhoea?What should I do if I become pregnant while taking it?