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Medicines diclofenac sodium + misoprostolQuestion & answer

diclofenac sodium + misoprostol · Medicine question

Can it be used while breastfeeding?

iatroX medicinesPublished 19 August 2026Reviewed 19 August 2026

The answer

Answer

No. Active misoprostol metabolite enters breast milk and could cause diarrhoea in the infant.

Sources for this answer

Arthrotec 50 Tabletsemc · SmPC Current selected SmPC · Version 27
Arthrotec 75 modified-release Tabletsemc · SmPC Current selected SmPC · Version 28
NHS Specialist Pharmacy Service

NHS Specialist Pharmacy Service · NHS medicine guidance

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The full medicine guide

diclofenac sodium + misoprostol

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More questions about diclofenac sodium + misoprostol

Why does this combination contain two active ingredients?Does it prevent every stomach ulcer?Can the tablets be crushed or chewed?Can I take ibuprofen with it?What should I do if it causes diarrhoea?What should I do if I become pregnant while taking it?