Answer
Yes. Systemic absorption can cause a slow or irregular heartbeat, low blood pressure or worsening heart failure, particularly in susceptible people.
Sources for this answer
- Brimonidine tartrate/Timolol 2mg/ml + 5mg/ml eye drops, solution — Current selected SmPCemc · Summary of Product Characteristics
- NHSNHS · NHS medicine guidance
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.