Answer
Yes. Nitrate tolerance can develop during sustained exposure; report reduced effectiveness.
Sources for this answer
- Minitran 5 mg/ 24 h, transdermal patch — Current selected SmPCemc · Summary of Product Characteristics
- Glyceryl trinitrate Macure — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.