Answer
Fluoxetine can reduce activation of tamoxifen by inhibiting CYP2D6. An alternative antidepressant should be considered where possible.
Sources for this answer
- UK GovernmentUK Government · Reputable Web
- Fluoxetine 20mg Capsules — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.