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Medicines cobicistatQuestion & answer

cobicistat · Medicine question

Can cobicistat be taken with St John’s wort?

iatroX medicinesPublished 19 August 2026Reviewed 19 August 2026

The answer

Answer

No. It can reduce cobicistat and protease-inhibitor exposure, risking treatment failure and resistance.

Sources for this answer

Tybost 150mg film coated tabletemc · SmPC Current selected SmPC · Version 18

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The full medicine guide

cobicistat

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