Answer
No. The combination is contraindicated because ciprofloxacin can greatly increase tizanidine exposure, causing excessive sedation and low blood pressure.
Sources for this answer
- Ciprofloxacin 250 mg film-coated tablets — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.