Answer
Yes. Some antidepressants increase the risk of serotonin syndrome or seizures, and monoamine oxidase inhibitors are contraindicated with tramadol.
Sources for this answer
- NHSNHS · NHS medicine guidance
- Tramadol hydrochloride 50 mg/ml solution for injection or infusion — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.