Answer
Yes, concomitant use of andexanet alfa with dalteparin sodium (Fragmin) may reduce dalteparin’s anticoagulant effect because andexanet alfa binds to heparin-bound antithrombin III; interaction studies have only been conducted in adults.
Sources for this answer
- Fragmin 12,500 IU/0.5ml solution for injectionPfizer Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 13Document updated
Sources checked