Answer
Yes, localised lightening (hypopigmentation) and darkening (hyperpigmentation) of skin have been reported after Aldara (imiquimod) 5% cream use, and follow-up information suggests these changes may be permanent in some patients.
Sources for this answer
- Aldara 5% CreamViatris (formerly Mylan or Upjohn) · emc · SmPC §4.8 Undesirable effects · Version 25Document updated
Sources checked