Executive summary
Biliary colic classically causes episodic RUQ/epigastric pain (often post-fatty meal), sometimes radiating to the back/right shoulder, with nausea/vomiting. The primary care risk is missing complications: acute cholecystitis, ascending cholangitis, or acute pancreatitis.
Differentiate uncomplicated biliary colic from complications
- Uncomplicated biliary colic: severe pain lasting minutes–hours, afebrile, improves between episodes.
- Acute cholecystitis: persistent RUQ pain >6 hours, fever, RUQ tenderness/positive Murphy’s, raised inflammatory markers.
- Ascending cholangitis: fever + jaundice + RUQ pain (Charcot triad), can deteriorate rapidly → emergency.
- Pancreatitis: severe epigastric pain radiating to back, vomiting, systemic unwellness; check amylase/lipase in hospital pathway.
Primary care investigations and immediate management
- Bloods: FBC, CRP, LFTs, U&E; consider amylase if available locally (but suspected pancreatitis generally needs ED).
- Imaging: ultrasound is first-line for gallstones; many areas arrange via surgical/gastro pathway.
- Analgesia: NSAIDs are often effective (if safe) ± opioid. Antiemetic if needed. Avoid delaying referral if recurrent.
Diet: short-term reduction in fatty foods may reduce attacks but is not definitive treatment.
Referral thresholds (pragmatic)
- Same-day ED: suspected cholecystitis, cholangitis, pancreatitis, sepsis, persistent vomiting/dehydration, or jaundice.
- Elective surgical referral: recurrent biliary colic, complications history, or patient preference with documented stones.
FAQ
Transparency
This page is an educational, clinician-written summary of publicly available NICE guidance intended for trained healthcare professionals. It uses original wording (not copied text) and should be used alongside the full NICE source, local pathways, and clinical judgement. Doses provided are for general reference; always check the BNF/SPC.