A 55-year-old man on ICU has TTP with ADAMTS13 less than 5%. What is the immediate first-line treatment?...

Question

A 55-year-old man on ICU has TTP with ADAMTS13 less than 5%. What is the immediate first-line treatment?

Accepted Answer

Urgent plasma exchange - removes pathogenic anti-ADAMTS13 antibodies and ultra-large vWF multimers while replacing functional ADAMTS13; mortality exceeds 90% without treatment; platelet transfusion is relatively contraindicated as it may fuel microthrombosis

Answer

Platelet transfusion

Answer

IV heparin

Answer

Steroids alone

Answer

Observation

uk-fficm MCQ (SBA): TTP - Plasma Exchange

A 55-year-old man on ICU has TTP with ADAMTS13 less than 5%. What is the immediate first-line treatment?