A 62-year-old man on ICU has severe heart failure (EF 15%) and is on optimal medical therapy including sacubitril/valsartan. What is the mechanism of ...

Question

A 62-year-old man on ICU has severe heart failure (EF 15%) and is on optimal medical therapy including sacubitril/valsartan. What is the mechanism of action of sacubitril/valsartan (Entresto)?

Accepted Answer

Sacubitril is a neprilysin inhibitor (increases natriuretic peptides by preventing their degradation) and valsartan is an ARB (blocks angiotensin II) - the combined effect reduces neurohormonal activation, promotes natriuresis/vasodilation, and reduces cardiac remodelling

Answer

Pure beta-blocker

Answer

Calcium channel blocker

Answer

Direct renin inhibitor

Answer

Aldosterone antagonist

uk-fficm MCQ (SBA): ARNI Mechanism

A 62-year-old man on ICU has severe heart failure (EF 15%) and is on optimal medical therapy including sacubitril/valsartan. What is the mechanism of action of sacubitril/valsartan (Entresto)?