A 50-year-old woman on ICU requires a blood transfusion. She has anti-Kell antibodies identified on her group and screen. What is the clinical significance and management? A Anti-Kell antibodies have no clinical significance B Anti-Kell antibodies are clinically significant alloantibodies that can cause haemolytic transfusion reactions and haemolytic disease of the fetus/newborn - only Kell-negative (K-negative) blood should be transfused, which may take longer to source from the blood bank C Anti-Kell is the same as anti-K D These antibodies always cause anaphylaxis E Anti-Kell antibodies resolve spontaneously
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