A 65-year-old man on ICU has septic shock secondary to E. coli bacteraemia from a urinary source. He has been on IV meropenem for 72 hours. Blood cultures at 48 hours remain positive for E. coli. What does persistent bacteraemia at 48 hours suggest?AThe antibiotics are working - no change neededBPersistent bacteraemia suggests inadequate source control (e.g. undrained collection, obstructed urinary tract), inadequate antibiotic therapy (wrong agent, subtherapeutic dosing, resistant organism), or an endovascular source (e.g. endocarditis, infected vascular graft) - urgent reassessment is requiredCBlood cultures should not be repeatedDSwitch to oral antibioticsEPersistent bacteraemia is normal and expectedCheck my answer